Long-lived intestinal tuft cells serve as colon cancer–initiating cells

Long-lived intestinal tuft cells serve as colon cancer-initiating cells.

Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth-sustaining stem cells. DCLK1⁺ tuft cells are increased in inflammation-induced carcinogenesis; however, the role of these cells within the gastrointestinal epithelium and their potential as cancer-initiating cells are poorly understood. Here, using a BA...

Langerhans cells serve as immunoregulatory cells by activating NKT cells.

Ultraviolet exposure alters the morphology and function of epidermal Langerhans cells (LCs), which play a role in UV-induced immune suppression. It is generally believed that UV exposure triggers the migration of immature LCs from the skin to the draining lymph nodes (LNs), where they induce tolerance. However, because most of the previous studies employed in vitro UV-irradiated LCs, the data g...

DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium.

Cancer. The authors thank Drs D. Fisher and A. Camasses for helpful discussion.

Long-Lived Bone Marrow Plasma Cells Are

Long-Lived Epidermal Cancer-Initiating Cells

Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population, as well as an economic load to the health care system; yet treatments of these preventable cancers remain ineffective. Studies estimate that there has been a 2-fold increase in the incidence of NMSCs between the 1960s and 1980s. The...